Blar i Brage NIH på forfatter "Coffey, Vernon G."

Viser treff 1-4 av 4

    • An epigenetic clock for human skeletal muscle 

      Voisin, Sarah; Harvey, Nicholas R; Haupt, Larisa M; Griffiths, Lyn R; Aston, Kevin J; Coffey, Vernon G.; Doering, Thomas M; Thompson, Jamie-Lee M; Benedict, Christian; Cedernaes, Jonathan; Lindholm, Malene E; Craig, Jeffrey M; Rowlands, David S; Sharples, Adam; Horvath, Steve; Eynon, Nir (Peer reviewed; Journal article, 2020)
      Background: Ageing is associated with DNA methylation changes in all human tissues, and epigenetic markers can estimate chronological age based on DNA methylation patterns across tissues. However, the construction of the ...

    • Exercise is associated with younger methylome and transcriptome profiles in human skeletal muscle 

      Voisin, Sarah; Seale, Kirsten; Jacques, Macsue; Landen, Shanie; Coffey, Vernon G.; Walsh, Colum; Davison, Gareth; McBride, Catherine; Irwin, Rachelle; Hansson, Ola; Asplund, Olof; Harvey, Nicholas R.; Haupt, Larisa M.; Griffiths, Lyn R.; Ashton, Kevin J.; Thompson, Jamie-Lee M.; Doering, Thomas M.; Lindholm, Maléne E.; Sharples, Adam P.; Eynon, Nir (Peer reviewed; Journal article, 2023)
      Exercise training prevents age-related decline in muscle function. Targeting epigenetic aging is a promising actionable mechanism and late-life exercise mitigates epigenetic aging in rodent muscle. Whether exercise training ...

    • Meta-analysis of genome-wide DNA methylation and integrative omics of age in human skeletal muscle 

      Voisin, Sarah; Jacques, Macsue; Landen, Shanie; Harvey, Nicholas R.; Haupt, Larisa M.; Griffiths, Lyn R.; Gancheva, Sofiya; Ouni, Meriem; Jähnert, Marcus; Ashton, Kevin J.; Coffey, Vernon G.; Thompson, Jamie-Lee M.; Doering, Thomas M.; Gabory, Anne; Junien, Claudine; Caiazzo, Robert; Verkindt, Hélène; Raverdy, Violetta; Pattou, Francois; Froguel, Philippe; Blocquiaux, Sara; Thomis, Martine; Roden, Michael; Horvath, Steve; Eynon, Nir; Craig, Jeffrey M.; Sharples, Adam P.; Schürmann, Annette (Peer reviewed; Journal article, 2021)
      Background Knowledge of age-related DNA methylation changes in skeletal muscle is limited, yet this tissue is severely affected by ageing in humans. Methods We conducted a large-scale epigenome-wide association ...

    • Modulating exercise-induced hormesis: does less equal more? 

      Peake, Jonathan M.; Markworth, James F.; Nosaka, Kazunori; Raastad, Truls; Wadley, Glenn D.; Coffey, Vernon G. (Journal article; Peer reviewed, 2015-08-01)
      Hormesis encompasses the notion that low levels of stress stimulate or upregulate existing cellular and molecular pathways that improve the capacity of cells and organisms to withstand greater stress. This notion underlies ...